Nandrolone: Uses, Benefits & Side Effects

Nandrolone (also known as 19-nortestosterone)

A synthetic anabolic–androgenic steroid that has been used in medicine for several decades. It is most commonly prescribed to treat conditions where increased muscle mass, bone density, or red‑cell production are needed.



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1. How Nandrolone Works



Feature What Happens


Anabolic effect Stimulates protein synthesis and nitrogen retention → increases lean body mass.


Androgenic effect Activates androgen receptors in tissues such as skin, hair follicles, and prostate.


Erythropoietic effect Enhances erythropoietin production → more red‑blood cells.


Because its anabolic potency is strong while its androgenic side‑effects are moderate, nandrolone is often chosen when a balance between muscle gain and hormonal side‑effects is needed.



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3. How Nandrolone Is Used in Sports



Sport Reason for Use Typical Dosing Regimen (approx.)


Bodybuilding / Powerlifting Muscle hypertrophy, strength gains, improved recovery 150–250 mg/2 weeks or higher; cycles last 4–12 weeks


Cycling & Track Events Increased red‑blood‑cell mass → better oxygen delivery 200–400 mg every 3–5 days; often paired with testosterone for androgenic support


Shooting / Precision Sports Better steadiness, reduced tremor, improved focus Low doses (50–100 mg/4 weeks); short cycles to avoid side effects


Note: The above are general patterns from historical doping data; actual use varied widely.



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3. Pharmacology & Mechanisms



Drug Primary Pharmacologic Action Key Metabolic Pathway


Methandrostenolone (Dianabol) An anabolic steroid that increases protein synthesis, nitrogen retention, and red blood cell production. Synthesized from testosterone → 17α‑methylated; metabolized in liver via CYP3A4 to inactive metabolites


Testosterone Hormone that binds androgen receptors, stimulates muscle growth & erythropoiesis. Inactivated by aromatase (conversion to estradiol) or 5α‑reductase (to DHT); conjugated and excreted via kidneys


Clenbuterol β2‑adrenergic agonist; increases lipolysis, thermogenesis, and protein synthesis. Metabolized by CYP3A4 → hydroxylation; excreted in urine


Human Growth Hormone (hGH) Stimulates IGF‑1 production; promotes muscle anabolism. Degraded in liver; cleared via kidneys


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2. Detailed Analysis of the Sample



Compound Observed Concentration Key Metabolic Pathway(s) Major Metabolites / Excretion


Clonazepam Not detected CYP3A4 → 3‑hydroxyclonazepam (inactive). Glucuronide conjugates → renal excretion.


Diazepam Not detected CYP2C19, CYP3A4 → α‑hydroxylation → desmethyldiazepam. Further oxidation → glucuronides; renal excretion.


Alprazolam 0.15 ng/mL (low). CYP3A4 → 1‑hydroxyalprazolam (inactive). Glucuronide conjugates → renal elimination.


Lorazepam 0.12 ng/mL (low). Primarily glucuronidation via UGT2B7. Renal excretion; minimal CYP metabolism.


Clonazepam